There is a difference between what I actually want and what I want to have fantasies about. (...) There is a part of my imagination which is a playground, a playground in which I am queen. It fulfils my need to have a fantasy land, and that need may be born of creativity as well as lack or repression. Our fantasies are about exploration and experimentation and the power of the imagination. Looked at intelligently, they can reveal a great deal. But there is a difference between fantasising and thinking about our hopes for the future.

Something must be radically wrong with a culture and a civilisation when its youth begins to desert it. Youth is the natural time for revolt, for experiment, for a generous idealism that is eager for action. Any civilisation which has the wisdom of self-preservation will allow a certain margin of freedom for the expression of this youthful mood. But the plain, unpalatable fact is that in America today that margin of freedom has been reduced to the vanishing point. Rebellious youth is not wanted here. In our environment there is nothing to challenge our young men; there is no flexibility, no colour, no possibility for adventure, no chance to shape events more generously than is permitted under the rules of highly organised looting. All our institutional life combines for the common purpose of blackjacking our youth into the acceptance of the status quo; and not acceptance of it merely, but rather its glorification.

By experimenting with sympathetic joy, we break from the constricted world of individual struggle and see that joy exists in more places than we have yet imagined.

Sometimes the best way to learn a lesson isn't just hearing the words, but putting it into practice by experimenting with it and finding its truth for yourself instead of taking someone else’s word for it.

Mathematics is not a deductive science - that's a cliche. When you try to prove a theorem, you don't just list the hypotheses, and then start to reason. What you do is trial and error, experimentation, guesswork.

We know a lot nowadays about how to extrapolate from rats to people, but we don't only have to rely on that. In a sense we've made ourselves into experimental animals. There are too many of us, too crowded, in an environment we've poisoned with our own-uh-byproducts. Now when this happens to a wild species, or to rats in a lab, the next generation turns out weaker and slower and more timid. This is a defense mechanism.

I didn't want a world in which I had to choose between blind human babies and tortured monkey ones. To be frank, that's the sort of choice I expect science to protect me from, not give me.

Wisdom is nothing more than confirmed imagination: just because one did not study for his exam does not mean that he should leave it blank.

But he was a perfect gentleman, Aunt Amelia. He did not even try to kiss me, though he wanted to. ... You always tell me I must be receptive to broadening experiences. That would have been a broadening experience. And, from what I have observed, a very enjoyable one.

As a result of its investigation, the NIH said that to qualify for funding, all proposals for research on human subjects had to be approved by review boards—independent bodies made up of professionals and laypeople of diverse races, classes, and backgrounds—to ensure that they met the NIH’s ethics requirements, including detailed informed consent. Scientists said medical research was doomed. In a letter to the editor of Science, one of them warned, “When we are prevented from attempting seemingly innocuous studies of cancer behavior in humans … we may mark 1966 as the year in which all medical progress ceased.